Endocrine Abstracts

Background: Families with inherited forms of diabetes insipidus (DI) have been described since the mid 19th century. Depending on the involved gene, the disorder is transmitted in autosomal dominant, autosomal recessive, or X-linked fashion.Nephrogenic DI: Patients typically have a severe phenotype manifesting shortly after birth. They are most often males with X-linked disease due to variations in the vasopressin V2 receptor (AVPR2) gene. Rarely, variat...

Background/Introduction: Diabetic ketoacidosis (DKA) is a severe complication of diabetes mellitus type 1 (T1DM) with potentially life-threatening course. Data on patient knowledge about DKA in German-speaking countries is rare. Thus, we aimed to gather data about T1DM patients’ knowledge in terms of DKA.Methods: Together with two T1DM patients and an experienced diabetes counselor, we developed an anonymous questionnaire covering general knowledge ...

Introduction: The syndrome of inappropriate antidiuresis (SIADH) is the most common cause of hypoosmolality. Ectopic AVP hypersecretion has long been considered as the primaryn mechanism of SIADH. But different types of osmoregulatory defect in AVP release have been described in this disorder. A comprehensive characterization of these different forms of SIADH in a large cohort of patients may provide important new insights into the still incompletely understood pathophysiology...

Background: The water deprivation test as the accepted gold standard in the differential diagnosis of polyuria polydipsia syndrome can be associated with a decrease in extracellular fluid volume in patients with diabetes insipidus (DI). We herein evaluated mid-regional pro-atrial natriuretic peptide (MR-proANP) as marker of extracellular body volume in patients with diabetes insipidus compared to primary polydipsia (PP), at baseline and after water deprivation.<p class="ab...

Introduction: The correct differential diagnosis of the disorders related to polyuria–polydipsia syndrome (PPS) is mandatory since inadequate treatment may lead to serious complications. The diagnostic gold standard is the water deprivation test (WDT) with direct or indirect measurement of plasma vasopressin (AVP). But test interpretation is problematic, and direct measurement of AVP is hampered by methodological difficulties. The aim of this study was to evaluate the dia...

Introduction: Systemic glucocorticoid therapy may put patients at risk for later adrenal failure during times of stress, but tapering increases cumulative steroid exposure. We prospectively evaluated adrenal function and clinically relevant hypocortisolism after abruptly stopping prednisone treatment in patients with exacerbated COPD.Methods: This is a pre-specified analysis of the REDUCE randomized trial (Journal of American Medical Association...